2. Signaling Pathways
  3. Immunology/Inflammation
  4. Nuclear Factor of activated T Cells (NFAT)

Nuclear Factor of activated T Cells (NFAT)

Nuclear factor of activated T cells (NFAT) proteins are a family of Ca2+/calcineurin-dependent transcription factors that were initially identified as inducible nuclear factors that could bind the interleukin-2 (IL-2) promoter in activated T cells. However, when all of the proteins of the NFAT family had been isolated and molecularly characterized, it became clear that their expression was not limited to T cells. Recent work has uncovered new regulatory roles for NFAT proteins in diverse organs, including the central nervous system, blood vessels, heart, kidney, bone, skeletal muscle and haematopoietic stem cells. For examples, cells in the vessel wall display a diverse array of Ca2+ signaling modalities, which are subject to change during disease. The fact that NFAT proteins are able to decode and translate these signals into changes in gene expression makes them potential regulators of vascular pathogenesis.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1026
    NFAT Inhibitor-1
    		99.71%
    NFAT Inhibitor (VIVIT peptide) is a cell-permeable peptide inhibitor of nuclear factor of activated Tcells (NFAT) that selectively inhibits calcineurin-mediated dephosphorylation of NFAT.
    NFAT Inhibitor-1
  • HY-112125A
    KRN2 bromide
    		98.13%
    KRN2 (bromide) is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 0.1 μM.
    KRN2 bromide
  • HY-112126
    KRN5
    		98.76%
    KRN5, a derivative of KRN2, is an oral active Nuclear factor of activated T cells 5 (NFAT5) suppressor, with an IC50 of 750 nM. KRN5 has potential to treat NFAT5-mediated Chronic Arthritis.
    KRN5
  • HY-108544
    INCA-6
    		98.85%
    INCA-6 (Triptycene-1,4-quinone) is a cell-permeable NFAT inhibitor. INCA-6 specifically blocks targeting of NFAT(P) substrate to the ?calcineurin (CN) phosphatase site and is an effective inhibitor of CN-NFAT signaling.
    INCA-6
  • HY-14369
    Elagolix sodium
    		Inhibitor 99.94%
    Elagolix sodium is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
    Elagolix sodium
  • HY-126754
    Archangelicin
    		Inhibitor
    Archangelicin is an inhibitor for cAMP-phosphodiesterase (cAMP-PDE) with IC50 >400 μM. Archangelicin inhibits nuclear factor of activated T cell (NFAT) with IC50 of 9 μM. Archangelicin exhibits antitumor and anti-inflammatory.
    Archangelicin
  • HY-19486
    UR-1505
    		Inhibitor
    UR-1505 is a nuclear factor of activated T cells (NF-AT) inhibitor. UR-1505 can suppress CD3/CD28 induced T cell proliferation, increase p27KIP levels, and induce G1/S cell cycle arrest. UR-1505 can also inhibit the production of IL-5 and IFN-γ in activated T cells. UR-1505 has immunomodulatory properties and can be used in the study of atopic dermatitis.
    UR-1505
  • HY-132243
    NFAT Inhibitor-3
    		Inhibitor
    NFAT Inhibitor-3 (Compound 10) is a factor nuclear factor of activated T cells (NFAT) inhibitor. NFAT Inhibitor-3 inhibits IL-2 production. NFAT Inhibitor-3 binds in a sequence-selective manner directly to DNA. NFAT Inhibitor-3 can be used for the research of transcription factor dysregulation.
    NFAT Inhibitor-3
  • HY-147369
    NFATc1-IN-1
    		Inhibitor 99.65%
    NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclast formation, with an IC50 of 1.57 μM. NFATc1-IN-1 shows anti-osteoclastogenic effects through reducing the RANKL-induced nuclear translocation of NFATc1. NFATc1-IN-1 can be used for osteoclastic diseases research.
    NFATc1-IN-1
  • HY-14789
    (R)-Elagolix
    		Inhibitor
    Elagolix is a highly effective, selective, oral-active, short-term, non-peptide gonadotropin-releasing hormone receptor (GnRH receptor) antagonist (KD = 54 pM) and NFAT inhibitor, which can be used to study pain related to endometriosis. .
    (R)-Elagolix
  • HY-P1430A
    11R-VIVIT TFA
    		99.22%
    11R-VIVIT TFA is a cell-permeable nuclear factor of activated T cells (NFAT) inhibitor. 11R-VIVIT TFA can be used for the research of podocyte and diabetic nephropathy.
    11R-VIVIT TFA
  • HY-136427
    KRM-III
    		98.08%
    KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity.
    KRM-III
  • HY-126030
    (+)-Syringaresinol
    		99.50%
    (+)-Syringaresinol, a lignan, is a NFAT transcription factor inhibitor, with an IC50 of 329.4 μM. (+)-Syringaresinol also can be used for the research of lymphocytic leukemia.
    (+)-Syringaresinol
  • HY-117987
    CPS-11
    		Activator 99.39%
    CPS-11 (N-(Hydroxymethyl)thalidomide) a Thalidomide (HY-14658) analogue, is a potent anti-cancer agent. CPS-11 inhibits NF-κB, activates NFAT, and repress cytokine expression through elevated ROS. CPS-11 exhibits a wider activity spectrum and higher potency against MM (multiple myeloma) cell lines.
    CPS-11
  • HY-112125
    KRN2
    KRN2 is a selective inhibitor of nuclear factor of activated T cells (NFAT5), with an IC50 of 100 nM. KRN2 has potential to treat NFAT5-mediated Chronic Arthritis.
    KRN2
  • HY-W019721
    Cyclosporin D
    		99.85%
    Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A. Cyclosporin A is a potent immunosuppressant agent, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc).
    Cyclosporin D
  • HY-N4053
    Heraclenin
    		99.59%
    Heraclenin, a natural furanocoumarin, significantly inhibits T cell receptor-mediated proliferation in human primary T cells in a concentration-dependent manner by targeting nuclear factor of activated T-cells (NFAT).
    Heraclenin
  • HY-134891
    HMBPP lithium
    		Inhibitor
    HMBPP (lithium) is an activator for human Vγ9/Vδ2 T cells. HMBPP exhibits phagostimulant property in mosquitos.
    HMBPP lithium
  • HY-139464
    Q134R
    		99.55%
    Q134R, a neuroprotective hydroxyquinoline derivative that suppresses nuclear factor of activated T cell (NFAT) signaling. Q134R can across blood-brain barrier. Q134R has the potential for Alzheimer's disease (AD) and aging-related disorders research.
    Q134R
  • HY-N11775
    Eudebeiolide B
    		Inhibitor
    Eudebeiolide B is a compound that can be isolated from Salvia plebeia R. Br. Eudebeiolide B inhibits osteoclastogenesis by regulating RANKL-induced NF-κB, c-Fos and calcium signaling. Eudebeiolide B can be used for osteoclast-related diseases research.
    Eudebeiolide B
Cat. No. Product Name / Synonyms Application Reactivity